Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.
Appl Environ Microbiol. 2011 Sep;77(18):6733-6. doi: 10.1128/AEM.00746-11. Epub 2011 Jul 29.
Chronological gene expression patterns of biofilm-forming cells are important to understand bioactivity and pathogenicity of biofilms. For Porphyromonas gingivalis ATCC 33277 biofilm formation, the number of genes differentially regulated by more than 1.5-fold was highest during the growth stage (312/2,090 genes), and some pathogen-associated genes were time-dependently controlled.
生物膜形成细胞的时间基因表达模式对于理解生物膜的生物活性和致病性非常重要。对于牙龈卟啉单胞菌 ATCC 33277 生物膜的形成,在生长阶段(312/2090 个基因),有超过 1.5 倍差异调控的基因数量最高,一些与病原体相关的基因是时间依赖性控制的。