定量蛋白质组学分析揭示了肠致病性大肠杆菌中 EscL-EscQ-EscN 型 III 复合物的形成。
Quantitative proteomic analysis reveals formation of an EscL-EscQ-EscN type III complex in enteropathogenic Escherichia coli.
机构信息
Michael Smith Laboratories, Vancouver, British Columbia V6T 1Z4, Canada.
出版信息
J Bacteriol. 2011 Oct;193(19):5514-9. doi: 10.1128/JB.05235-11. Epub 2011 Jul 29.
Abstract
We characterized Orf5 and SepQ, two type III secretion (T3S) system proteins in enteropathogenic Escherichia coli, and showed that they are essential for T3S, associated with the bacterial membrane, and interact with EscN. Our findings suggest that Orf5 and SepQ are homologs of YscL and YscQ from Yersinia, respectively.
摘要
我们对肠致病性大肠杆菌中的两种 III 型分泌系统（T3S）蛋白 Orf5 和 SepQ 进行了特征描述，并表明它们对 T3S 是必需的，与细菌膜相关，并与 EscN 相互作用。我们的研究结果表明，Orf5 和 SepQ 分别是耶尔森氏菌 YscL 和 YscQ 的同源物。
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