金鸡纳生物碱也由一种生活在金鸡纳植物中的内生丝状真菌产生。
Cinchona alkaloids are also produced by an endophytic filamentous fungus living in cinchona plant.
作者信息
Maehara Shoji, Simanjuntak Partomuan, Kitamura Chinami, Ohashi Kazuyoshi, Shibuya Hirotaka
机构信息
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2011;59(8):1073-4. doi: 10.1248/cpb.59.1073.
PMID:21804259
Abstract
We report that the endophytic filamentous fungus Diaporthe sp., isolated from Cinchona ledgeriana and cultivated in a synthetic liquid medium, produces Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine). This shows that Cinchona alkaloids are produced not only in Cinchona plant cells, but also in endophytic microbe cells.
摘要
我们报告称，从金鸡纳树中分离并在合成液体培养基中培养的内生丝状真菌Diaporthe sp. 能够产生金鸡纳生物碱（奎宁、奎尼丁、辛可尼丁和辛可宁）。这表明金鸡纳生物碱不仅在金鸡纳植物细胞中产生，也在内生微生物细胞中产生。
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