Maehara Shoji, Simanjuntak Partomuan, Kitamura Chinami, Ohashi Kazuyoshi, Shibuya Hirotaka
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 1 Gakuen-cho, Fukuyama, Hiroshima 729-0292, Japan.
Chem Pharm Bull (Tokyo). 2012;60(10):1301-4. doi: 10.1248/cpb.c12-00545. Epub 2012 Aug 2.
We report that an endophytic filamentous fungus species of the genus Diaporthe isolated from Cinchona ledgeriana (Rubiaceae) produces Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) upon cultivation in a synthetic liquid medium. This study provides evidence that Cinchona alkaloids are produced not only in Cinchona plant cells, but also in the endophytic microbe cells, and will help to elucidate the relationship between endophytic microbes and their host plants.
我们报告称，从金鸡纳树（茜草科）中分离出的一种内生丝状真菌——间座壳属真菌，在合成液体培养基中培养时会产生金鸡纳生物碱（奎宁、奎尼丁、辛可尼丁和辛可宁）。这项研究提供了证据，表明金鸡纳生物碱不仅在金鸡纳植物细胞中产生，也在内生微生物细胞中产生，这将有助于阐明内生微生物与其宿主植物之间的关系。
