从金鸡纳树中分离出的内生炭角菌将金鸡纳生物碱转化为1-N-氧化物衍生物。
Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp isolated from Cinchona pubescens.
作者信息
Shibuya Hirotaka, Kitamura Chinami, Maehara Shoji, Nagahata Marie, Winarno Hendig, Simanjuntak Partomuan, Kim Hye-Sook, Wataya Yusuke, Ohashi Kazuyoshi
机构信息
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2003 Jan;51(1):71-4. doi: 10.1248/cpb.51.71.
PMID:12520132
Abstract
The microbial transformation of four Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) by endophytic fungi isolated from Cinchona pubescens was investigated. The endophytic filamentous fungus Xylaria sp. was found to transform the Cinchona alkaloids into their 1-N-oxide derivatives.
摘要
研究了从金鸡纳树中分离出的内生真菌对四种金鸡纳生物碱（奎宁、奎尼丁、辛可尼丁和辛可宁）的微生物转化。发现内生丝状真菌炭角菌属将金鸡纳生物碱转化为它们的1-N-氧化物衍生物。
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