Calan Mehmet, Calan Ozlem, Gonen Mustafa Sait, Bilgir Ferda, Kebapcilar Levent, Kulac Esin, Cinali Turker, Bilgir Oktay
Department of Internal Medicine, Division of Endocrinology and Metabolism Izmir, Izmir Dokuz Eylul University, Turkey.
Intern Med. 2011;50(15):1529-35. doi: 10.2169/internalmedicine.50.4297. Epub 2011 Aug 1.
Increased levels of selectins, adhesion molecules, hs-CRP and homocysteine are considered important as indicators of atherosclerosis. There is a significant amount of evidence that high LDL-C levels are a risk factor for coronary artery disease, whereas the relevance of isolated triglycerides is controversial. The present study aims to compare the levels of homocysteine, hs-CRP, E-selectin, sP-selectin, VCAM-1, ICAM-1 in patients with isolated hypertriglyceridemia and polygenic hypercholesterolemia.
The following three groups were formed: polygenic hypercholesterolemia group (n=30), isolated hypertriglyceridemia group (n=30) and control group (n=30). These three groups were matched in terms of BMI, waist circumference and gender. Plasma high sensitive CRP, homocysteine, sVCAM-1, sICAM-1, sP-selectin, sE-Selectin levels of patients in these three groups were measured.
In the present study, mean values for sE-selectin, sVCAM-1 and sICAM-1 in the polygenic hypercholesterolemia group were significantly higher than in the other two groups (p<0.001). Homocysteine and hs-CRP levels were higher in the polygenic hypercholesterolemia group, compared to the isolated hypertriglyceridemia group (p=0.019, p<0.001; respectively) and the control group (p<0.001, p<0.001; respectively). Comparison of patients with hypertriglyceridemia to individuals in the control group did not yield a significant difference in terms of sE-selectin, sP-selectin, sVCAM-1, sICAM and homocysteine (p>0.05), where as the hs-CRP value was significantly higher in patients with isolated hypertriglyceridemia compared to the control group (p=0.001).
The increase of adhesion molecules, homocysteine and hs-CRP in polygenic hypercholesterolemia subjects compared to the isolated hypertriglyceridemia group reflects their high cardiovascular risk.
选择素、黏附分子、超敏C反应蛋白（hs-CRP）和同型半胱氨酸水平升高被认为是动脉粥样硬化的重要指标。有大量证据表明，高LDL-C水平是冠状动脉疾病的危险因素，而单纯甘油三酯的相关性存在争议。本研究旨在比较单纯高甘油三酯血症患者和多基因高胆固醇血症患者的同型半胱氨酸、hs-CRP、E-选择素、可溶性P-选择素（sP-selectin）、血管细胞黏附分子-1（VCAM-1）、细胞间黏附分子-1（ICAM-1）水平。
组建以下三组：多基因高胆固醇血症组（n = 30）、单纯高甘油三酯血症组（n = 30）和对照组（n = 30）。这三组在体重指数、腰围和性别方面相匹配。测量这三组患者血浆中的高敏CRP、同型半胱氨酸、可溶性VCAM-1、可溶性ICAM-1、sP-选择素、可溶性E-选择素水平。
在本研究中，多基因高胆固醇血症组的可溶性E-选择素、可溶性VCAM-1和可溶性ICAM-1平均值显著高于其他两组（p < 0.001）。与单纯高甘油三酯血症组（分别为p = 0.019，p < 0.001）和对照组（分别为p < 0.001，p < 0.001）相比，多基因高胆固醇血症组的同型半胱氨酸和hs-CRP水平更高。将高甘油三酯血症患者与对照组个体进行比较，在可溶性E-选择素、sP-选择素、可溶性VCAM-1、可溶性ICAM和同型半胱氨酸方面未产生显著差异（p > 0.05），而单纯高甘油三酯血症患者的hs-CRP值显著高于对照组（p = 0.001）。
与单纯高甘油三酯血症组相比，多基因高胆固醇血症患者中黏附分子、同型半胱氨酸和hs-CRP的增加反映了他们较高的心血管风险。
