Department of Medical, Surgical and Health Sciences, University of Trieste, Cattinara Teaching Hospital, 34149 Trieste, Italy.
Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy.
Int J Mol Sci. 2018 Dec 14;19(12):4058. doi: 10.3390/ijms19124058.
Lipids and inflammation regulate each other. Early studies on this topic focused on the systemic effects that the acute inflammatory response-and interleukins-had on lipid metabolism. Today, in the era of the obesity epidemic, whose primary complications are cardio-metabolic diseases, attention has moved to the effects that the nutritional environment and lipid derangements have on peripheral tissues, where lipotoxicity leads to organ damage through an imbalance of chronic inflammatory responses. After an overview of the effects that acute inflammation has on the systemic lipid metabolism, this review will describe the lipid-induced immune responses that take place in peripheral tissues and lead to chronic cardio-metabolic diseases. Moreover, the anti-inflammatory effects of lipid lowering drugs, as well as the possibility of using anti-inflammatory agents against cardio-metabolic diseases, will be discussed.
脂质和炎症相互调节。早期关于这一主题的研究集中在急性炎症反应和白细胞介素对脂质代谢的系统影响上。如今，在肥胖症流行的时代，其主要并发症是心血管代谢疾病，人们的注意力已经转移到营养环境和脂质紊乱对周围组织的影响上，脂毒性通过慢性炎症反应失衡导致器官损伤。在概述急性炎症对全身脂质代谢的影响之后，本综述将描述发生在周围组织中的脂质诱导的免疫反应，这些反应导致慢性心血管代谢疾病。此外，还将讨论降脂药物的抗炎作用以及使用抗炎药物治疗心血管代谢疾病的可能性。
