Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Epidemiol. 2011;21(5):319-28. doi: 10.2188/jea.JE20100162. Epub 2011 Jul 30.
Data on secular trends in adolescent obesity and dyslipidemia are limited. Data on obesity status collected during 3 surveys were used to evaluate these trends in obesity and dyslipidemia among Tehranian adolescents and to assess the likelihood of risk factors for cardiovascular disease.
We analyzed data for adolescents (age 10 to 19 years) from 3 cross-sectional surveys of the Tehran Lipid and Glucose Study: 1999-2001 (n = 3010, 47.2% males), 2002-2005 (n = 1107, 48.4% males), and 2006-2008 (n = 1090, 46.6% males). Overweight and abdominal obesity were defined using Iranian body mass index (BMI) percentiles, International Obesity Task Force (IOTF) criteria, and Iranian waist circumference (WC) charts. Hypertension was defined by using the National Heart, Lung, and Blood Institute's recommended cut points, and dyslipidemia was defined according to the recent recommendations of the American Heart Association.
The overall adjusted prevalences of "at risk for overweight" and overweight changed from 13% and 8% (using Iranian cutoffs), respectively, and 14.8% and 4.7% (using IOTF criteria) in 1999-2001 to 19% and 15% (Iranian cutoffs) and 23.0% and 9.2% (IOTF criteria) in 2006-2008 (P < 0.01 for all comparisons). The prevalence of abdominal obesity increased in males from 14.5% in 1999-2001 to 33.3% in 2006-2008 (P < 0.001). Almost half the adolescents had low high-density lipoprotein cholesterol (HDL-C) in the 3 surveys. In all surveys, as BMI and WC increased, multivariate age- and sex-adjusted odds ratios of low HDL-C and high triglyceride levels significantly increased. Overweight was associated with a greater likelihood of these risk factors, as compared with increased WC.
Overweight and abdominal obesity are increasing in Tehranian adolescents, and these increases are accompanied by abnormalities in levels of serum triglyceride and HDL-C.
关于青少年肥胖和血脂异常的长期趋势的数据有限。本研究使用三次调查中收集的肥胖状况数据，评估德黑兰青少年肥胖和血脂异常的长期趋势，并评估心血管疾病风险因素的可能性。
我们分析了 3 次德黑兰血脂和血糖研究横断面调查中青少年（年龄 10 至 19 岁）的数据：1999-2001 年（n=3010，男性占 47.2%）、2002-2005 年（n=1107，男性占 48.4%）和 2006-2008 年（n=1090，男性占 46.6%）。超重和腹型肥胖采用伊朗体重指数（BMI）百分位、国际肥胖工作组（IOTF）标准和伊朗腰围（WC）图表进行定义。高血压通过美国国立心肺血液研究所推荐的切点定义，血脂异常根据美国心脏协会的最新建议进行定义。
整体调整后的“超重风险”和超重的发生率分别从 1999-2001 年的 13%和 8%（采用伊朗切点），以及 14.8%和 4.7%（采用 IOTF 标准）变为 2006-2008 年的 19%和 15%（采用伊朗切点）以及 23.0%和 9.2%（采用 IOTF 标准）（所有比较均 P<0.01）。男性的腹型肥胖患病率从 1999-2001 年的 14.5%增加到 2006-2008 年的 33.3%（P<0.001）。在三次调查中，几乎一半的青少年的高密度脂蛋白胆固醇（HDL-C）水平较低。在所有调查中，随着 BMI 和 WC 的增加，校正年龄和性别后的多变量比值比显著增加，超重和 WC 增加与低 HDL-C 和高甘油三酯水平的可能性增加相关。
德黑兰青少年的超重和腹型肥胖正在增加，而这些增加伴随着血清甘油三酯和 HDL-C 水平的异常。
