Department of Community Medicine, West Virginia University School of Medicine, Morgantown, WV 26506, USA.
J Toxicol Sci. 2011 Aug;36(4):403-10. doi: 10.2131/jts.36.403.
Perfluorocarbons from common household products such as food containers, stain- resistant protection for clothing, furniture and carpets, paints, and fire-fighting foams are found in soil, water, plants, animal and human serum worldwide. Previous research has shown a significant association between these chemicals and thyroid disease in women. The present data from the C8 Health Project assessed thyroid function in a cross-sectional analysis of 52,296 adults with a year or more of exposure to perfluorooctanoate (PFOA) from drinking water. Outcomes were: thyroxine, T3 uptake, and thyroid stimulating hormone (TSH). Analyses were stratified by gender and age group (< 20 - < 50 years and > 50). Both PFOA and perfluorooctane sulfonate (PFOS) were associated with significant elevations in serum thyroxine and a significant reduction in T3 uptake in all participants. There were also significant gender/PFOS interactions for T3( )uptake and thyroxine, as well as gender/PFOA interactions for T3 uptake. Results provide evidence for disruption of thyroid function related to these common chemicals and possible mechanisms are discussed.
日常生活用品（如食品容器、衣物、家具和地毯的防污保护、涂料以及灭火泡沫）中含有的全氟碳化合物在世界各地的土壤、水、植物、动物和人体血清中均有发现。先前的研究表明，这些化学物质与女性的甲状腺疾病之间存在显著关联。目前，C8 健康项目的数据评估了来自饮用水的全氟辛烷酸（PFOA）暴露一年或更长时间的 52296 名成年人的甲状腺功能，采用横断面分析。结果为：甲状腺素、T3 摄取率和促甲状腺激素（TSH）。分析按性别和年龄组（<20-<50 岁和>50 岁）分层。全氟辛酸（PFOA）和全氟辛烷磺酸（PFOS）均与血清甲状腺素显著升高以及 T3 摄取率显著降低有关。所有参与者中 T3 摄取率和甲状腺素也存在性别/PFOS 相互作用，T3 摄取率存在性别/PFOA 相互作用。研究结果为这些常见化学物质与甲状腺功能紊乱之间的关系提供了证据，并讨论了可能的机制。
