Karasek D, Vaverkova H, Frysak Z, Halenka M, Jackuliakova D, Novotny D, Lukes J
3rd Department of Internal Medicine, University Hospital, Olomouc, Czech Republic.
Int Angiol. 2011 Oct;30(5):441-50.
The plasma levels of soluble intercellular cell adhesion molecule-1 (s-ICAM-1) and soluble vascular cell adhesion molecule-1 (s-VCAM-1) were assessed in clinically asymptomatic subjects to compare them between normolipidemic and various dyslipidemic phenotypes. The associations between soluble cell adhesion molecules (s-CAMs) and risk factors for atherosclerosis, markers of insulin resistance, and the intima-media thickness of the common carotid artery (IMT) were evaluated, too.
Thwo hundred and thirty-four asymptomatic subjects were divided into four dyslipidemic phenotypes (DLP) according to apolipoprotein B (apoB) and triglycerides (TG): DLP1 (N.=58, apoB<1.2 g/L and TG<1.5 mmol/L), DLP2 (N.=47, apoB<1.2 g/L and TG≥1.5 mmol/L), DLP3 (N.=31, apoB≥1.2 g/L and TG<1.5 mmol/L) and DLP4 (N.=98, apoB≥1.2 g/L and TG≥1.5 mmol/L). DLP1 (normo-apoB /normo-TG) served as a control group.
A significant difference in s-ICAM-1 between DLP1 (502.0 [457.1-568.2] ng/mL) and DLP4 (567.9 [502.8-692.1] ng/mL, P<0.001) was found. No significant differences in s-VCAM-1 between DLPs were apparent. S-ICAM-1 was independently predicted by HDL-cholesterol, non-HDL-cholesterol, proinsulin, C-peptide, waist, systolic and diastolic blood pressure. S-VCAM-1 was predicted only by age and systolic blood pressure. Both s-CAMs were detected as independent predictors for IMT, which was significantly increased in DLP 4.
The elevation of s-ICAM-1 was presented only in patients with simultaneously elevated TG and apoB (DLP4) in comparison with normolipidemic subjects. Patients with DLP 4 had significantly increased IMT, which was independently predicted by levels of s-ICAM-1 and of s-VCAM-1. These findings pointed out DLP4 subjects as individuals with the highest risk for early manifestation of atherosclerosis.
评估临床无症状受试者血浆中可溶性细胞间黏附分子-1（s-ICAM-1）和可溶性血管细胞黏附分子-1（s-VCAM-1）水平，以比较正常血脂血症和各种血脂异常表型之间的差异。同时评估可溶性细胞黏附分子（s-CAMs）与动脉粥样硬化危险因素、胰岛素抵抗标志物以及颈总动脉内膜中层厚度（IMT）之间的关联。
根据载脂蛋白B（apoB）和甘油三酯（TG）将234名无症状受试者分为四种血脂异常表型（DLP）：DLP1（n = 58，apoB < 1.2 g/L且TG < 1.5 mmol/L），DLP2（n = 47，apoB < 1.2 g/L且TG≥1.5 mmol/L），DLP3（n = 31，apoB≥1.2 g/L且TG < 1.5 mmol/L）和DLP4（n = 98，apoB≥1.2 g/L且TG≥1.5 mmol/L）。DLP1（正常apoB/正常TG）作为对照组。
发现DLP1（502.0 [457.1 - 568.2] ng/mL）和DLP4（567.9 [502.8 - 692.1] ng/mL，P < 0.001）之间的s-ICAM-1存在显著差异。各DLP之间的s-VCAM-1无明显差异。s-ICAM-1由高密度脂蛋白胆固醇、非高密度脂蛋白胆固醇、胰岛素原、C肽、腰围、收缩压和舒张压独立预测。s-VCAM-1仅由年龄和收缩压预测。两种s-CAMs均被检测为IMT的独立预测因子，IMT在DLP4中显著增加。
与正常血脂血症受试者相比，s-ICAM-1升高仅出现在TG和apoB同时升高的患者（DLP4）中。DLP4患者的IMT显著增加，其由s-ICAM-1和s-VCAM-1水平独立预测。这些发现指出DLP4受试者是动脉粥样硬化早期表现风险最高的个体。
