Karásek David, Vaverková Helena, Halenka Milan, Budíková Marie, Novotný Dalibor
3rd Department of Internal Medicine, Teaching Hospital, Olomouc, Czech Republic.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Jun;149(1):101-8. doi: 10.5507/bp.2005.012.
Familial combined hyperlipidemia (FCH) is the most common familial hyperlipidemia with a high risk for early atherosclerosis. The aim of this study was to compare levels of soluble intercellular cell adhesion molecule 1 (s-ICAM-1) and soluble vascular cell adhesion molecule 1 (s-VCAM-1) in asymptomatic members of FCH families with healthy controls and to determine the relation between s-ICAM-1, s-VCAM-1 and risk factors accompanying FCH. We also investigated the association between adhesion molecules and the intima-media thickness (IMT) of the common carotid artery, a recognized morphological marker of early atherosclerosis. 82 members of 29 FCH families were divided into the 2 groups: HL (probands and hyperlipidemic first-degree relatives, n = 47) and NL (normolipidemic first-degree relatives, n = 35). The control groups--HL-C (n = 20) and NL-C (n = 20)--consisted of sex- and age-matched healthy individuals. Hyperlipidemic members had significantly higher concentration of s-ICAM-1 (633.7 +/- 169.6 ng/ml versus 546.2 +/- 155.9 ng/ml, p < 0.05). The elevation of s-VCAM-1 was not significant (880.8 +/- 202.9 ng/ml versus 826.5 +/- 174.6 ng/ml, N.S.). Levels of s-ICAM-1 and of s-VCAM-1 in normolipidemic relatives were not significantly different from the control group (530.8 +/- 113.9 ng/ml versus 530.0 +/- 101.0 ng/ml and 860.2 +/- 265.7 ng/ml versus 822.1 +/- 197.0 ng/ml respectively). There was a significant correlation between s-ICAM-1 and apoB (r = 0.42; p < 0.01) in hyperlipidemic subjects and between s-ICAM-1 and proinsulin (r = 0.54; p < 0.01) in normolipidemic subjects. S-ICAM-1 correlated with IMT (r = 0.32; p < 0.05) in all members of FCH families. The increase of s-ICAM-1 in asymptomatic hyperlipidemic members of FCH families reflects their high cardiovascular risk. The positive association between s-ICAM-1 and IMT could indicate s-ICAM-1 as a potential predictor of atherosclerosis manifestation.
家族性混合型高脂血症（FCH）是最常见的家族性高脂血症，早期发生动脉粥样硬化的风险很高。本研究的目的是比较FCH家族无症状成员与健康对照者中可溶性细胞间黏附分子1（s-ICAM-1）和可溶性血管细胞黏附分子1（s-VCAM-1）的水平，并确定s-ICAM-1、s-VCAM-1与FCH伴随的危险因素之间的关系。我们还研究了黏附分子与颈总动脉内膜中层厚度（IMT）之间的关联，IMT是早期动脉粥样硬化公认的形态学标志物。29个FCH家族的82名成员被分为两组：HL组（先证者和高脂血症一级亲属，n = 47）和NL组（血脂正常的一级亲属，n = 35）。对照组——HL-C组（n = 20）和NL-C组（n = 20）——由年龄和性别匹配的健康个体组成。高脂血症成员的s-ICAM-1浓度显著更高（633.7±169.6 ng/ml对546.2±155.9 ng/ml，p < 0.05）。s-VCAM-1的升高不显著（880.8±202.9 ng/ml对826.5±174.6 ng/ml，无统计学意义）。血脂正常亲属的s-ICAM-1和s-VCAM-1水平与对照组无显著差异（分别为530.8±113.9 ng/ml对530.0±101.0 ng/ml和860.2±265.7 ng/ml对822.1±197.0 ng/ml）。在高脂血症受试者中s-ICAM-1与载脂蛋白B显著相关（r = 0.42；p < 0.01），在血脂正常受试者中s-ICAM-1与胰岛素原显著相关（r = 0.54；p < 0.01）。在FCH家族的所有成员中，s-ICAM-1与IMT相关（r = 0.32；p < 0.05）。FCH家族无症状高脂血症成员中s-ICAM-1的升高反映了他们较高的心血管风险。s-ICAM-1与IMT之间的正相关可能表明s-ICAM-1是动脉粥样硬化表现的潜在预测指标。
