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高危型人乳头瘤病毒与南非女性性工作者感染艾滋病毒有关。

High-risk human papillomavirus is associated with HIV acquisition among South African female sex workers.

作者信息

Auvert Bertran, Marais Dianne, Lissouba Pascale, Zarca Kevin, Ramjee Gita, Williamson Anna-Lise

机构信息

CESP INSERM-UVSQ U1018, Villejuif, France.

出版信息

Infect Dis Obstet Gynecol. 2011;2011:692012. doi: 10.1155/2011/692012. Epub 2011 Jul 3.

DOI:10.1155/2011/692012
PMID:21804752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3143430/
Abstract

BACKGROUND

Mounting evidence suggests an association between human papillomavirus (HPV) and HIV acquisition. This study aimed to explore this association among South African female sex workers (FSWs).

METHODS

We used data from 88 HIV-negative FSWs who participated in a vaginal gel (COL-1492) trial. Cervicovaginal rinse samples, obtained before HIV-seroconversion, were genotyped into high-risk (HR-) and low-risk (LR-) HPV. HIV-adjusted hazard ratios (aHRs) and 95% confidence intervals (CI) were estimated using Cox survival analysis.

RESULTS

HR- and LR-HPV prevalences were 70.5% (95% CI:60.5-79.2) and 60.2% (95% CI:49.9-70.0), respectively. Twenty-five women HIV seroconverted. Controlling for background characteristics and other sexually transmitted infections, HIV aHR increased by a factor of 1.7 (95% CI:1.01-2.7, P(linear trend) = 0.045) for an increase of one unit of the number of HR-HPV genotypes.

CONCLUSIONS

HIV seroconversion among FSWs is associated with genital HR-HPV infection. Further investigation is warranted, including testing the possible protective effect of available HPV vaccines on HIV acquisition.

摘要

背景

越来越多的证据表明人乳头瘤病毒（HPV）与感染HIV之间存在关联。本研究旨在探讨南非女性性工作者（FSW）中的这种关联。

方法

我们使用了88名参与阴道凝胶（COL-1492）试验的HIV阴性FSW的数据。在HIV血清转化之前采集的宫颈阴道冲洗样本被基因分型为高危（HR-）和低危（LR-）HPV。使用Cox生存分析估计HIV调整后的风险比（aHRs）和95%置信区间（CI）。

结果

HR-HPV和LR-HPV的患病率分别为70.5%（95%CI：60.5-79.2）和60.2%（95%CI：49.9-70.0）。25名女性发生了HIV血清转化。在控制背景特征和其他性传播感染的情况下，HR-HPV基因型数量每增加一个单位，HIV的aHR增加1.7倍（95%CI：1.01-2.7，P（线性趋势）=0.045）。

结论

FSW中的HIV血清转化与生殖器HR-HPV感染有关。有必要进行进一步调查，包括测试现有HPV疫苗对HIV感染可能的保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1104/3143430/a208bd0a9f5a/IDOG2011-692012.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1104/3143430/528c14797771/IDOG2011-692012.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1104/3143430/a208bd0a9f5a/IDOG2011-692012.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1104/3143430/528c14797771/IDOG2011-692012.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1104/3143430/a208bd0a9f5a/IDOG2011-692012.002.jpg

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