Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
Evid Based Complement Alternat Med. 2011;2011:691067. doi: 10.1155/2011/691067. Epub 2011 Jul 26.
In order to avoid low absorption, incorporation, and undesirable side effects of inorganic oxovanadium compounds, the antidiabetic activities of organic oxovanadium (IV) compounds in alloxan-induced diabetic mice were investigated. Vanadyl carboxymethyl carrageenan (VOCCA) and vanadyl carboxymethyl chitosan (VOCCH) were synthesized and administrated through intragastric administration in different doses for 20 days in alloxan-induced diabetic mice. Glibenclamide was administrated as the positive control. Our results showed that low-dose group, middle-dose group, and high-dose group of VOCCA and VOCCH could significantly reduce the levels of blood glucose (P < 0.05) compared with untreated group, but not in normal mice. Besides, high-dose groups of VOCCA and VOCCH exhibited more significant hypoglycemic activities (P < 0.01). After treated with VOCCH, the oral glucose tolerance of high-dose group of VOCCH was improved compared with model control group (P < 0.05).
为了避免无机氧钒化合物吸收不良、不易被人体吸收和产生不良副作用，本研究考察了氧钒（IV）有机化合物在四氧嘧啶诱导的糖尿病小鼠中的降血糖活性。合成了氧钒羧甲基卡拉胶（VOCCA）和氧钒羧甲基壳聚糖（VOCCH），并通过灌胃给药，在四氧嘧啶诱导的糖尿病小鼠中连续给药 20 天，不同剂量给药。格列本脲作为阳性对照。结果表明，与未处理组相比，VOCCA 和 VOCCH 的低剂量组、中剂量组和高剂量组均能显著降低血糖水平（P<0.05），但对正常小鼠没有作用。此外，VOCCA 和 VOCCH 的高剂量组表现出更显著的降血糖活性（P<0.01）。经 VOCCH 处理后，高剂量组的口服葡萄糖耐量较模型对照组有所改善（P<0.05）。
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