通过烯丙基和腈的还原交叉和分子内偶联反应合成偕胺。

Homoallylic amines by reductive inter- and intramolecular coupling of allenes and nitriles.

机构信息

Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA 15260, USA.

出版信息

Beilstein J Org Chem. 2011;7:824-30. doi: 10.3762/bjoc.7.94. Epub 2011 Jun 17.

DOI:10.3762/bjoc.7.94

PMID:21804878

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3135093/

Abstract

The one-pot hydrozirconation of allenes and nitriles followed by an in situ transmetalation of the allylzirconocene with dimethylzinc or zinc chloride provides functionalized homoallylic amines. An intramolecular version of this process leads to 3-aminotetrahydrofurans and 3-aminotetrahydropyrans.

摘要

一锅法将丙二烯和腈进行水合锆反应，然后用二甲基锌或氯化锌将烯丙基锆进行原位转金属化，得到官能化的同型烯丙基胺。该过程的分子内版本生成 3-氨基四氢呋喃和 3-氨基四氢吡喃。