Department of Endocrinology, Command Hospital, Lucknow, UP, 226002, India.
Pituitary. 2012 Dec;15 Suppl 1:S49-52. doi: 10.1007/s11102-011-0336-x.
Pseudoacromegaly is a condition characterized by cutaneous manifestations of growth hormone excess but with normal growth hormone levels. This is described in patients with severe insulin resistance, pachydermoperiostitis, burnt out acromegaly and with intake of drugs like Minoxidil. Severe thyroid hormone deficiency rarely present with similar picture and the issue is further complicated in presence of pituitary hyperplasia. We report an unusual presentation of primary hypothyroidism with pseudoacromegaly and thyrotroph hyperplasia mimicking a pituitary macroadenoma. The thyrotroph hyperplasia resolved completely with levothyroxine therapy.
假性肢端肥大症是一种以生长激素过多的皮肤表现为特征，但生长激素水平正常的疾病。这种疾病发生在严重胰岛素抵抗、厚皮性骨膜病、消耗性肢端肥大症和服用米诺地尔等药物的患者中。严重的甲状腺激素缺乏症很少出现类似的表现，而在存在垂体增生的情况下，问题会更加复杂。我们报告了一例原发性甲状腺功能减退症伴假性肢端肥大症和促甲状腺激素细胞增生的罕见表现，这种增生类似于垂体大腺瘤。促甲状腺激素细胞增生在用左甲状腺素治疗后完全消退。
