University of Turin, Turin, Italy.
J Mater Sci Mater Med. 2011 Oct;22(10):2387-95. doi: 10.1007/s10856-011-4399-z. Epub 2011 Jul 31.
Cosmeto-textile applications can be used in the treatment of chronic venous insufficiency in legs by means of elastic bandages loaded with natural products which possess flebotonic properties. We have developed an efficient synthetic procedure for the preparation of β-cyclodextrin (β-CD)-grafted viscose by means of a 2-step ultrasound-assisted reaction. The highly grafted fabric bearing bis-urethane bridged β-CD has been characterized by ATR-FTIR and CP-MAS spectra and by an empiric colorimetric method which used phenolphthalein as the CD guest. We have also developed a suitable cosmetic preparation containing natural substances and extracts (aescin, menthol, Centella asiatica and Ginkgo biloba) to recharge the CD-grafted textile. The efficacy of the new cosmeto-textile has been corroborated by in vitro studies of diffusion through membranes, cutaneous permeation and accumulation in porcine skin. Aescin was taken as a reference compound and its concentration in the different compartments was monitored by HPLC analysis. This cost effective cosmeto-textile shows excellent application compliance and is easily recharged and so has the strong base characteristics needed for possible industrial production.
通过使用含有具有静脉活性的天然产物的弹性绷带，可将化妆-纺织应用于腿部慢性静脉功能不全的治疗。我们通过两步超声辅助反应开发了一种用于制备β-环糊精（β-CD）接枝粘胶纤维的有效合成方法。高度接枝的纤维用双异氰酸酯桥联的β-CD 进行了 ATR-FTIR 和 CP-MAS 光谱以及使用酚酞作为 CD 客体的经验比色法进行了表征。我们还开发了一种合适的化妆品制剂，该制剂含有天然物质和提取物（七叶皂苷、薄荷醇、积雪草和银杏叶），以对 CD 接枝的纺织品进行再充电。通过体外研究通过膜的扩散、皮肤渗透和在猪皮中的积累，证实了新型化妆-纺织物的功效。七叶皂苷被用作参考化合物，通过 HPLC 分析监测其在不同隔室中的浓度。这种具有成本效益的化妆-纺织物具有出色的应用顺应性，并且易于再充电，因此具有可能进行工业生产所需的强碱特性。
