Levendoglu H, Cox C A, Nadimpalli V
Division of Gastroenterology and Surgical Pathology, Cook County Hospital, Hektoen Institute for Medical Research, Chicago, Illinois.
Dig Dis Sci. 1990 Apr;35(4):519-25. doi: 10.1007/BF01536929.
Tumors of the gut with composite features of both adenocarcinoma and carcinoid have been recognized mainly in the appendix. There also have been isolated reports of similar tumors arising from other parts of the gastrointestinal tract. It is generally concluded that these tumors have better prognosis than adenocarcinomas of the gastrointestinal tract. We reported six patients with composite tumors arising from the stomach in one, small intestine in two, cecum in two, and rectum in one patient. Clinical presentations in each was suggestive of malignancy with extension to either serosa and/or lymph nodes. Metastasis to liver was present in two patients. Histologically, the tumor showed glands with surface microvilli resembling adenocarcinoma and also organoid pattern with neurosecretory granules in cells resembling carcinoid. Two patients died three and nine months after surgery. The clinical presentation, findings at operation, and the postsurgical course of these six patients reveal that these tumors behave more like an adenocarcinoma than carcinoid and do not appear to have a better prognosis than ordinary adenocarcinoma.
具有腺癌和类癌复合特征的肠道肿瘤主要在阑尾中被识别出来。也有关于胃肠道其他部位出现类似肿瘤的个别报道。一般认为，这些肿瘤的预后比胃肠道腺癌要好。我们报告了6例复合肿瘤患者，其中1例起源于胃，2例起源于小肠，2例起源于盲肠，1例起源于直肠。每例患者的临床表现均提示为恶性肿瘤，已侵犯至浆膜层和/或淋巴结。2例患者出现肝转移。组织学上，肿瘤表现为具有表面微绒毛的腺体，类似腺癌，同时也具有类器官模式，细胞内有神经分泌颗粒，类似类癌。2例患者在手术后3个月和9个月死亡。这6例患者的临床表现、手术所见及术后病程表明，这些肿瘤的行为更像腺癌而非类癌，且预后似乎并不比普通腺癌更好。
