Lyss A P, Thompson J J, Glick J H
Cancer. 1981 Aug 1;48(3):833-9. doi: 10.1002/1097-0142(19810801)48:3<833::aid-cncr2820480328>3.0.co;2-z.
Patients with ulcerative colitis are at increased risk of developing adenocarcinoma of the colon. The authors describe a patient whose colonic neoplasm demonstrated histologic characteristics of both an adenocarcinoma and a carcinoid tumor and which was pathologically identical to a appendiceal adenocarcinoid. Because individual tumor cells stained positively for both mucin and argentaffin granules, the histologic picture is unique among the malignancies seen in patients with ulcerative colitis and cannot be explained as a composite of two independent neoplasms that have grown together. Since the tumor discussed seems to have originated from a single cell line, the theory that carcinoids develop from neural crest cells which have migrated to embryonic gut endoderm must be regarded with considerable doubt.
溃疡性结肠炎患者患结肠癌的风险增加。作者描述了一名患者，其结肠肿瘤具有腺癌和类癌肿瘤的组织学特征，并且在病理上与阑尾腺癌类癌相同。由于单个肿瘤细胞对粘蛋白和嗜银颗粒均呈阳性染色，因此该组织学表现在溃疡性结肠炎患者所见的恶性肿瘤中是独特的，不能解释为两个独立生长在一起的肿瘤的复合体。由于所讨论的肿瘤似乎起源于单一细胞系，因此类癌由迁移至胚胎肠道内胚层的神经嵴细胞发展而来的理论必须受到相当大的质疑。
