Moini Ashraf, Kiani Kiandokht, Bahmanabadi Akram, Akhoond Mohammadreza, Akhlaghi Aliasghar
Department of Endocrinology and Female Infertility, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Aust N Z J Obstet Gynaecol. 2011 Aug;51(4):315-20. doi: 10.1111/j.1479-828X.2011.01318.x. Epub 2011 Jun 9.
The present study aimed to evaluate the effect of removing cervical discharge prior to embryo transfer (ET) on pregnancy rates.
Five hundred and thirty women who were candidates for fresh ET in intracytoplasmic sperm injection (ICSI) cycles were randomly allocated to intervention or control groups. In the intervention group, the cervical canal was cleansed using sterile cotton swabs prior to ET. The control group had routine ET. Multiple logistic regression analysis was used to estimate the adjusted effect of removing the cervical discharge on pregnancy rates.
There was a significant difference in pregnancy rates between the two groups. The clinical pregnancy rate was 104/265 (39.2%) in the intervention group compared with 60/265 (22.6%) in the control group (P<0.001). The intervention group also had a higher implantation rate (20.5%) compared with the control group (12.2%; P<0.001). Additionally, the live birth rate in the intervention group (33.6%) was significantly higher than in the control group (17.4%; P<0.001). The logistic regression analysis indicated that the odds ratio of pregnancy in the intervention group was 2.297 (95% CI, 1.552-3.399) compared with the control group.
Removal of cervical discharge prior to ET may have a significant effect on the rate of implantation, pregnancy and live birth.
本研究旨在评估胚胎移植（ET）前清除宫颈分泌物对妊娠率的影响。
将530名计划在卵胞浆内单精子注射（ICSI）周期中进行新鲜胚胎移植的女性随机分为干预组和对照组。干预组在胚胎移植前用无菌棉签清洁宫颈管。对照组进行常规胚胎移植。采用多因素逻辑回归分析来评估清除宫颈分泌物对妊娠率的校正影响。
两组妊娠率存在显著差异。干预组临床妊娠率为104/265（39.2%），对照组为60/265（22.6%）（P<0.001）。干预组的着床率（20.5%）也高于对照组（12.2%；P<0.001）。此外，干预组的活产率（33.6%）显著高于对照组（17.4%；P<0.001）。逻辑回归分析表明，与对照组相比，干预组妊娠的优势比为2.297（95%CI，1.552 - 3.399）。
胚胎移植前清除宫颈分泌物可能对着床率、妊娠率和活产率有显著影响。
