Faculty of Medicine, Department of Urology, University of Inonu, Malatya, Turkey.
Andrologia. 2012 May;44 Suppl 1:454-61. doi: 10.1111/j.1439-0272.2011.01204.x. Epub 2011 Aug 2.
In this study, it was aimed to determinate beneficial effects of protocatechuic acid (PCA) against reproductive toxicity caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant. For this purpose, 28 rats were equally divided into four groups (control, TCDD 2 μg kg(-1) per week, PCA 100 mg kg(-1) per day and TCDD + PCA group), and compounds were orally administered for 45 days. The results indicated that TCDD induced oxidative stress via an increase in thiobarbituric acid-reactive substances levels and a decrease in reduced glutathione, catalase, glutathione peroxidise and SOD levels in male rats. In contrast, PCA treatment prevented toxic effects of TCDD in terms of oxidative stress. Additionally, sperm motility, sperm concentration and serum testosterone levels significantly decreased, and pathologic testicular damage increased with TCDD exposure. However, these effects of TCDD on sperm characteristics, histopathological changes and hormone levels were reversed by PCA treatment. In conclusion, it was found that TCDD exposure induced reproductive toxicity (oxidative, hormonal, histopathological and spermatological alternations) in male rats and PCA treatment could prevent toxic effects of TCDD. Thus, PCA may be useful for the prevention and treatment of reproductive toxicity caused by TCDD.
在这项研究中，旨在确定原儿茶酸（PCA）对环境污染物 2,3,7,8-四氯二苯并对二恶英（TCDD）引起的生殖毒性的有益作用。为此，将 28 只大鼠等分为四组（对照组、TCDD2μg/kg/周、PCA100mg/kg/天和 TCDD+PCA 组），并经口给予化合物 45 天。结果表明，TCDD 通过增加丙二醛反应物质的水平和降低还原型谷胱甘肽、过氧化氢酶、谷胱甘肽过氧化物酶和 SOD 的水平诱导雄性大鼠的氧化应激。相反，PCA 处理可预防 TCDD 的毒性作用，包括氧化应激。此外，精子活力、精子浓度和血清睾酮水平显著降低，TCDD 暴露导致睾丸组织病理学损伤增加。然而，PCA 处理逆转了 TCDD 对精子特征、组织病理学变化和激素水平的这些影响。总之，发现 TCDD 暴露会导致雄性大鼠生殖毒性（氧化、激素、组织病理学和精子发生改变），而 PCA 处理可预防 TCDD 的毒性作用。因此，PCA 可能有助于预防和治疗 TCDD 引起的生殖毒性。
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