Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.
Front Endocrinol (Lausanne). 2021 Nov 3;12:696106. doi: 10.3389/fendo.2021.696106. eCollection 2021.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a well-known environmental poison that exist in the environment for many years. However, its effect on the male reproductive system has not been clearly stated. We conducted a meta-analysis of the effect of TCDD on the male reproductive system of rodents about TCDD. Results showed that that TCDD exposure reduced the testis weight (weighted mean difference [WMD]: -0.035, 95% confidence interval [CI]: -0.046 to -0.025), sperm count (WMD: -35, 95% CI: -42.980 to -27.019), and blood testosterone concentration (WMD: -0.171, 95% CI: -0.269 to -0.073). According to our research results, TCDD can cause damage to the male reproductive system of rodents through direct or indirect exposure. In order to further explore the potential hazards of TCDD to humans, more human-related research needs to be carried out.
2,3,7,8-四氯二苯并对二恶英（TCDD）是一种众所周知的环境毒物，在环境中存在多年。然而，它对男性生殖系统的影响尚未得到明确说明。我们对 TCDD 对啮齿动物男性生殖系统的影响进行了荟萃分析。结果表明，TCDD 暴露降低了睾丸重量（加权均数差 [WMD]：-0.035，95%置信区间 [CI]：-0.046 至 -0.025）、精子计数（WMD：-35，95% CI：-42.980 至 -27.019）和血液睾酮浓度（WMD：-0.171，95% CI：-0.269 至 -0.073）。根据我们的研究结果，TCDD 可以通过直接或间接暴露对啮齿动物的男性生殖系统造成损害。为了进一步探索 TCDD 对人类的潜在危害，需要开展更多与人类相关的研究。
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