从当归中分离得到的 Z-藁本内酯可改善东莨菪碱诱导的小鼠记忆障碍。
Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice.
机构信息
Department of Pharmacology and Biopharmaceutics, Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China.
出版信息
Fitoterapia. 2011 Oct;82(7):1128-32. doi: 10.1016/j.fitote.2011.07.011. Epub 2011 Jul 23.
We investigated the effect of Z-ligustilide (LIG) on scopolamine-induced memory impairment in ICR mice. LIG (2.5-40 mg/kg) or tacrine (10 mg/kg) was orally administrated for 26 days. Behavior was examined in the Morris water maze and Y-maze after scopolamine administration (2 mg/kg, i.p.). The central acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) activities were assessed spectrophotometrically. LIG significantly improved spatial long-term memory and short-term memory impairment, inhibited AChE activity and increased ChAT activity. Moreover, LIG and tacrine showed the comparable efficacy in both neurobehavioral and cholinergic evaluation. These data suggest that LIG may alleviate memory deficits probably via enhancing cholinergic function.
我们研究了 Z-藁本内酯（LIG）对东莨菪碱诱导的 ICR 小鼠记忆障碍的影响。LIG（2.5-40 mg/kg）或他克林（10 mg/kg）经口给药 26 天。在东莨菪碱给药后（2 mg/kg，ip），在 Morris 水迷宫和 Y 迷宫中进行行为测试。通过分光光度法评估中枢乙酰胆碱酯酶（AChE）和胆碱乙酰转移酶（ChAT）活性。LIG 显著改善了空间长期记忆和短期记忆障碍，抑制了 AChE 活性并增加了 ChAT 活性。此外，LIG 和他克林在神经行为和胆碱能评估中显示出相当的疗效。这些数据表明，LIG 可能通过增强胆碱能功能来缓解记忆缺陷。
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