Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital and Centre for Healthy Ageing, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Arch Phys Med Rehabil. 2011 Aug;92(8):1185-93. doi: 10.1016/j.apmr.2011.03.009.
To investigate the effect of 12 weeks of strength training in combination with a nonsteroidal anti-inflammatory drug (NSAID), glucosamine, or placebo on muscle cross-sectional area (CSA), strength (primary outcome parameters), and function, power, pain, and satellite cell number (secondary outcome parameters) in patients with knee osteoarthritis (OA).
Double-blinded, randomized controlled trial.
Hospital.
Patients (N=36; 20 women, 16 men; age range, 50-70y) with bilateral tibiofemoral knee OA. A total of 181 patients were approached, and 145 were excluded.
Patients were randomly assigned to treatment with the NSAID ibuprofen (n=12), glucosamine (n=12), or placebo (n=12) during 12 weeks of quadriceps muscle strength training.
Muscle CSA and strength.
No differences between groups were observed in gains in muscle CSA. Training combined with ibuprofen increased maximal isometric strength by an additional .22Nm/kg (95% confidence interval [CI], .01-.42; P=.04), maximal eccentric muscle strength by .38Nm/kg (95% CI, .05-.70; P=.02), and eccentric muscle work by .27J/kg (95% CI, .01-.53; P=.04) in comparison with placebo. Training combined with glucosamine increased maximal concentric muscle work by an additional .24J/kg versus placebo (95% CI, .06-.42; P=.01).
In patients with knee OA, NSAID or glucosamine administration during a 12-week strength-training program did not improve muscle mass gain, but improved maximal muscle strength gain in comparison with treatment with placebo. However, we do not find that the benefits are large enough to justify taking NSAIDs or glucosamine.
研究 12 周的力量训练与非甾体抗炎药（NSAID）、氨基葡萄糖或安慰剂相结合对膝骨关节炎（OA）患者的肌肉横截面积（CSA）、力量（主要结局参数）以及功能、力量、疼痛和卫星细胞数量（次要结局参数）的影响。
双盲、随机对照试验。
医院。
36 名（20 名女性，16 名男性；年龄范围，50-70 岁）双侧胫股膝关节 OA 患者。共接触了 181 名患者，排除了 145 名患者。
患者在 12 周的股四头肌力量训练期间随机接受 NSAID 布洛芬（n=12）、氨基葡萄糖（n=12）或安慰剂（n=12）治疗。
肌肉 CSA 和力量。
组间肌肉 CSA 增加无差异。与安慰剂相比，联合布洛芬训练增加了 0.22Nm/kg（95%置信区间，0.01-0.42；P=.04）的最大等长力量、0.38Nm/kg（95%置信区间，0.05-0.70；P=.02）的最大离心肌肉力量和 0.27J/kg（95%置信区间，0.01-0.53；P=.04）的离心肌肉工作。与安慰剂相比，联合氨基葡萄糖训练增加了 0.24J/kg的最大向心肌肉工作（95%置信区间，0.06-0.42；P=.01）。
在膝骨关节炎患者中，在 12 周力量训练计划期间给予 NSAID 或氨基葡萄糖治疗不会增加肌肉质量增加，但与安慰剂相比，可提高最大肌肉力量增加。然而，我们认为这些益处还不够大，不足以证明服用 NSAID 或氨基葡萄糖是合理的。
