Čeh Tina, Šarabon Nejc
University of Primorska, Faculty of Health Sciences, Izola, Slovenia; Community Healthcare Centre Dr. Adolf Drolc, Maribor.
University of Primorska, Faculty of Health Sciences, Izola, Slovenia; S2P, Science to practice, Ltd., Laboratory for Motor Control and Motor Behavior, Ljubljana, Slovenia; InnoRennew Center of excellence, Izola.
Eur J Transl Myol. 2023 Nov 23;33(4):12013. doi: 10.4081/ejtm.2023.12013.
It is well known that different types of exercise significantly improve physical function and relieve pain in knee osteoarthritis (KOA) patients. The aim of this study was to investigate the added effects of glucosamine or glucosamine and chondroitin supplementation in combination with an exercise program in the management of KOA. The randomized controlled trials on adding glucosamine (G) or G combined with chondroitin (C) to an exercise program in the treatment of KOA were searched in the PubMed, Cochrane Central Register of Controlled Trials, PEDro, and Web of Science online databases. The Pedro scale tool was used to assess quality of literature. A meta-analysis was performed using the Review Manager 5.4 software. In total, 6 studies (including 297 participants) were included for the final meta-analysis. According to the PEDro scale, the average quality of the studies was rated as good (mean = 8.2 (2)). The results showed that the effect of G, or G and C, in combination with exercise is not significant, as indicated by the assessed knee pain (WOMAC pain: SMD -0.18, 95% CI -0.47 to 0.11, p = 0.23; and VAS pain: SMD -0.34, 95% CI -0.85 to 0.17, p = 0.20) and physical function (SMD -0.13, 95% CI -0.95 to 0.69, p = 0.76). Adding glucosamine alone or a combination of glucosamine and chondroitin to exercise, has no effect on knee pain and physical function compared with exercise alone in KOA patients. Keywords: treatment, dietary supplement, physical activity, older adults.
众所周知，不同类型的运动能显著改善膝关节骨关节炎（KOA）患者的身体机能并缓解疼痛。本研究旨在探讨补充氨基葡萄糖或氨基葡萄糖与软骨素联合补充剂，结合运动计划对KOA治疗的附加效果。在PubMed、Cochrane对照试验中央注册库、PEDro和科学网在线数据库中检索了关于在KOA治疗中，将氨基葡萄糖（G）或G与软骨素（C）联合添加到运动计划中的随机对照试验。使用PEDro量表工具评估文献质量。使用Review Manager 5.4软件进行荟萃分析。最终纳入6项研究（包括297名参与者）进行荟萃分析。根据PEDro量表，研究的平均质量被评为良好（均值 = 8.2（2））。结果显示，G或G与C结合运动的效果不显著，评估的膝关节疼痛（WOMAC疼痛：标准化均数差 -0.18，95%置信区间 -0.47至0.11，p = 0.23；视觉模拟评分法疼痛：标准化均数差 -0.34，95%置信区间 -0.85至0.17，p = 0.20）和身体机能（标准化均数差 -0.13，95%置信区间 -0.95至0.69，p = 0.76）表明了这一点。在KOA患者中，与单独运动相比，单独添加氨基葡萄糖或氨基葡萄糖与软骨素的组合对膝关节疼痛和身体机能没有影响。关键词：治疗、膳食补充剂、身体活动、老年人。
