Department of Pharmaceutical Sciences, University of Padua, Padova, Italy.
Chem Commun (Camb). 2011 Sep 21;47(35):9846-8. doi: 10.1039/c1cc12654g. Epub 2011 Aug 2.
The function of cell-specific ligands on gold nanoparticles can be selectively gated by the action of co-grafted thermosensitive polymers. Below the LCST the responsive chain-extended polymers prevent cell-surface receptors from accessing the affinity ligands while above the LCST, the polymers collapse exposing the ligands and allowing binding to receptors, which in turn promotes cell internalisation.
金纳米粒子上细胞特异性配体的功能可以通过共接枝热敏聚合物的作用选择性地关闭。低于 LCST 时，响应性的链扩展聚合物阻止细胞表面受体接近亲和配体，而高于 LCST 时，聚合物坍塌，暴露出配体并允许与受体结合，这反过来又促进了细胞内化。
