Won Sangho, Richards Sarah-Jane, Walker Marc, Gibson Matthew I
Department of Chemistry , University of Warwick , Coventry , CV4 7AL , UK . Email:
Department of Physics, University of Warwick , Coventry , CV4 7AL , UK.
Nanoscale Horiz. 2017 Mar 1;2(2):106-109. doi: 10.1039/c6nh00202a. Epub 2016 Dec 14.
Nature dynamically controls carbohydrate expression on cells rather than static presentation. Here we report synthetic glycosylated nanoparticles that contain polymeric 'gates' to enable external control ( temperature changes) of glycan surface expression, as an alternative to enzymatic control in nature. This approach offers a new dynamic multivalent scaffold for glycan recognition.
自然界动态地控制细胞上碳水化合物的表达，而非静态呈现。在此，我们报道了一种合成糖基化纳米颗粒，其含有聚合物“门”，能够实现对聚糖表面表达的外部控制（温度变化），以此作为自然界中酶促控制的替代方法。这种方法为聚糖识别提供了一种新的动态多价支架。
