Department of Dermatology, Father Muller Medical College and Hospital, Kankanady, Mangalore 575002, Karnataka, India.
Singapore Med J. 2011 Jul;52(7):e163-6.
Metastatic cancer of unknown primary (CUP) may unexpectedly manifest on the skin and subcutaneous tissue, prompting the patient to first visit a dermatologist. We describe an interesting case of cutaneous metastases from poorly differentiated adenocarcinoma of an unknown primary site in a 57-year-old man. The CUP had an unusually long period of indolence between presentation as a solitary axillary lymph node metastasis and rapid cutaneous dissemination. The possible causes of such a presentation are reviewed, and the management is briefly discussed. Diagnosis of unusual cutaneous manifestations of occult systemic malignancies could pose a diagnostic challenge to dermatologists.
不明原发灶转移性癌（CUP）可能会出乎意料地出现在皮肤和皮下组织，促使患者首先就诊于皮肤科。我们描述了一例有趣的病例，一名 57 岁男性患有来源不明的低分化腺癌，发生了皮肤转移。CUP 以孤立性腋窝淋巴结转移形式出现后，在发生快速皮肤播散前有一段异常长的惰性期。我们回顾了这种表现的可能原因，并简要讨论了其治疗方法。隐匿性全身恶性肿瘤的不常见皮肤表现的诊断可能对皮肤科医生构成诊断挑战。
