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[颗粒细胞瘤(阿布里科索夫瘤):对于微创切除而言,精确的术前诊断至关重要]

[Granular-cell tumor (Abrikossoff's tumor): precise preoperative diagnosis is crucial when for minimally-invasive resection].

作者信息

Karch H W, Gockel I, Goetz M, Kreft A, Lang H

机构信息

Praxis für Gastroenterologie, Kirn.

出版信息

Dtsch Med Wochenschr. 2011 Aug;136(31-32):1609-12. doi: 10.1055/s-0031-1281564. Epub 2011 Aug 1.

Abstract

HISTORY AND ADMISSION FINDINGS

A 38-year-old man was referred to a gastroenterologist because of thoracic pain and dysphagia of uncertain cause.

INVESTIGATIONS

Endoscopy revealed a centrally depressed, coarse submucosal tumor, 1.0 cm in diameter, in the anterior wall of the esophagus at about 35 cm from the teeth. Button-hole biopsy revealed histologically and immunohistochemically a granular cell tumor (Abrikossoff's tumor), positive for S-100 protein. CT-staging was unremarkable, except for a thickening of the distal esophageal wall.

TREATMENT AND COURSE

Minimally invasive submucosal resection was undertaken using the videoscopic/endoscopic rendezvous technique. Histological examination confirmed complete resection of the tumor. The clinical course was uneventful and endoscopy 6 and 12 weeks after the operation showed complete resection of the tumor.

CONCLUSION

An exact preoperative diagnosis beyond a mere description of site and morphology, but also providing the histopathological data creates favorable conditions for planning and performing a minimally invasive resection. Submucosal resection with the videoscopic/endoscopic in rendezvous technique offers the possibility of complete resection, which can often not be achieved in a submucosal tumor by only endoscopic resection.

摘要

病史与入院检查结果

一名38岁男性因胸痛和吞咽困难(病因不明)被转诊至胃肠病学家处。

检查

内镜检查发现距门齿约35cm处食管前壁有一个中央凹陷、粗糙的黏膜下肿瘤,直径1.0cm。咬取活检经组织学和免疫组织化学检查显示为颗粒细胞瘤(阿布里科索夫瘤),S-100蛋白呈阳性。CT分期未见明显异常,仅食管远端壁增厚。

治疗与病程

采用视频内镜会师技术进行微创黏膜下切除术。组织学检查证实肿瘤完全切除。临床过程顺利,术后6周和12周的内镜检查显示肿瘤完全切除。

结论

术前不仅要对病变部位和形态进行准确描述,还要提供组织病理学数据,这为规划和实施微创切除创造了有利条件。采用视频内镜会师技术进行黏膜下切除术可实现完全切除,而仅通过内镜切除黏膜下肿瘤往往无法做到这一点。

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