Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Medicina (Kaunas). 2022 Dec 7;58(12):1804. doi: 10.3390/medicina58121804.
Esophageal submucosal tumors are rare, but their pathological types are diverse. In addition to the relatively common leiomyomas, some rare submucosal lesions are occasionally reported. Waldeyer's ring is described as a unique subtype of mucosa-associated lymphoid tissue, located in the naso-oropharynx. Studies have reported that Waldeyer's ring is the most common site of primary extranodal lymphoma in the head and neck. Interestingly, we encountered an esophageal submucosal tumor-like lesion similar to the tonsillar structures of Waldeyer's ring. A 38-year-old man underwent esophagoscopy after experiencing swallowing discomfort for 3 months. A protruding submucosal mass with slightly rough mucosa was found at the cervical esophagus approximately 20 cm from the incisors. Considering the possibility of the coexistence of a submucosal tumor and a mucosal lesion, as well as the continuous symptoms of swallowing discomfort, the patient underwent endoscopic submucosal dissection. The lesion was removed en bloc. However, histology revealed a lesion similar to the tonsillar structure of Waldeyer's ring between the lamina propria and submucosa. The patient was followed up for 6 months without recurrence or complaints. We report a new submucosal lesion and discuss its origin and treatment. Diagnostic ESD might be an effective option until its malignant potential is clarified.
食管黏膜下肿瘤较为少见,但病理类型多样。除了较为常见的平滑肌瘤外,偶尔也会有一些罕见的黏膜下病变被报道。Waldeyer 环被描述为黏膜相关淋巴组织的一种独特亚型,位于鼻咽部。研究表明,Waldeyer 环是头颈部原发性结外淋巴瘤最常见的部位。有趣的是,我们遇到了一个类似于咽扁桃体结构的食管黏膜下肿瘤样病变。一位 38 岁男性因吞咽不适 3 个月接受了食管镜检查,在距切牙约 20cm 的颈段食管发现一处突出的黏膜下肿块,黏膜稍粗糙。考虑到黏膜下肿瘤和黏膜病变共存的可能性,以及持续存在的吞咽不适症状,患者接受了内镜黏膜下剥离术。整块切除了病变。然而,组织学显示在固有层和黏膜下层之间存在类似于 Waldeyer 环咽扁桃体结构的病变。患者随访 6 个月,无复发或不适。我们报告了一种新的黏膜下病变,并讨论了其起源和治疗。诊断性 ESD 可能是一种有效的选择,直到明确其恶性潜能。