Jin Miaomiao, Guo Qingming, Sun Xiaoping, Zhang Xuan, Lv Yaozhong, Xiao Wei
Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China.
Zhongguo Zhong Yao Za Zhi. 2011 Apr;36(8):1011-4.
To study the pharmacokinetics and bioavailability of ginkgolides sustained-release tablet and conventional tablet in Beagle dogs.
The concentrations of ginkgolides in plasma were determined by LC-MS. The main pharmacokinetic parameters of ginkgolides sustained-release tablet and conventional tablet in vivo were obtained using Pharmacokinetic software DAS 2.0.
The C(max) of grinkgolide A in ginkgolide sustained-release tablet and conventional tablet were 443.51, 1 039.30 microg x L(-1), respecitvely. t(max) were 2.92, 1.08 h, respectively. AUC(0-12h) were 1 808.21, 2 041.37 h x microg(-1) x L(-1), respectively. MRT were 5.18, 3.18 h, respectively. The relative bioavailability of ginkgolides A was 88.58%. The C(max) of ginkgolide B in ginkgolide sustained-release tablet and conventional tablet were 407.13, 547.38 microg x L(-1), respectively. t(max) were 2.92, 1.08 h, respectively. AUC(01-12 h) were 1 987.31, 1 748.04 h x microg(-1) x L(-1), respectively. MRT were 6.05, 4.98 h, respectively. The relative bioavailability of ginkgolides B was 113.69%.
The ginkgolides sustained-release tablets have good sustained release characteristics and are bioequivalent to the reference formulation.
研究银杏内酯缓释片与普通片在比格犬体内的药代动力学及生物利用度。
采用液相色谱-质谱联用法测定血浆中银杏内酯的浓度。运用药代动力学软件DAS 2.0获取银杏内酯缓释片与普通片在体内的主要药代动力学参数。
银杏内酯A缓释片与普通片中的C(max)分别为443.51、1 039.30 μg·L(-1)。t(max)分别为2.92、1.08 h。AUC(0-12h)分别为1 808.21、2 041.37 h·μg(-1)·L(-1)。MRT分别为5.18、3.18 h。银杏内酯A的相对生物利用度为88.58%。银杏内酯B缓释片与普通片中的C(max)分别为407.13、547.38 μg·L(-1)。t(max)分别为2.92、1.08 h。AUC(01-12 h)分别为1 987.31、1 748.04 h·μg(-1)·L(-1)。MRT分别为6.05、4.98 h。银杏内酯B的相对生物利用度为113.69%。
银杏内酯缓释片具有良好的缓释特性，与参比制剂生物等效。
