Zhang Xian-tao, Jiao Hao-yan, Suo Qi-liang
Guangdong Research Institute of Traditional Chinese Medicine, Guangzhou 510520, China.
Zhong Yao Cai. 2012 May;35(5):762-5.
To study the pharmacokinetics of ginkgolide B injection in Beagle dogs.
Determined the serum concentration of ginkgolide B by LC-MS and calculated its parameter of pharmacokinetics via DAS 2.0 software.
After intravenous drips of 0.62, 2.07 and 10.35 mg/kg ginkgolide B, parameters of pharmacokinetics of ginkgolide B were as follows: Tmax were 0.444, 1, 1 h; Cmax were 0.764, 3.024, 11.013 mg/L; AUC(0-1) were 1.007, 3.644, 16.646 mg x h/Lo.
Ginkgolide B has two compartment model in Beagle dogs.
研究银杏内酯B注射液在比格犬体内的药代动力学。
采用液相色谱-质谱联用法测定银杏内酯B的血清浓度，并通过DAS 2.0软件计算其药代动力学参数。
静脉滴注0.62、2.07和10.35mg/kg银杏内酯B后，银杏内酯B的药代动力学参数如下：达峰时间分别为0.444、1、1小时；峰浓度分别为0.764、3.024、11.013mg/L；0-1小时的血药浓度-时间曲线下面积分别为1.007、3.644、16.646mg·h/L。
银杏内酯B在比格犬体内呈二室模型。
