Núcleo de Estudos e Pesquisas em Atenção ao Uso de Drogas (NEPAD)-Universidade do Estado do Rio de Janeiro (State University of Rio de Janeiro), 20940-200 Rio de Janeiro, RJ, Brasil.
BMC Infect Dis. 2011 Aug 2;11:208. doi: 10.1186/1471-2334-11-208.
Hepatitis C virus (HCV) genotype (GT) has become an important measure in the diagnosis and monitoring of HCV infection treatment. In the United States (U.S.) HCV GT 1 is reported as the most common infecting GT among chronically infected patients. In Europe, however, recent studies have suggested that the epidemiology of HCV GTs is changing.
We assessed HCV GT distribution in 460 patients from three HCV-infected high risk populations in San Francisco, and examined patterns by birth cohort to assess temporal trends. Multiple logistic regression was used to assess factors independently associated with GT 1 infection compared to other GTs (2, 3, and 4).
Overall, GT 1 was predominant (72.4%), however younger injection drug users (IDU) had a lower proportion of GT 1 infections (54.7%) compared to older IDU and HIV-infected patients (80.5% and 76.6%, respectively). Analysis by birth cohort showed increasing proportions of non-GT 1 infections associated with year of birth: birth before 1970 was independently associated with higher adjusted odds of GT 1: AOR 2.03 (95% CI: 1.23, 3.34). African-Americans as compared to whites also had higher adjusted odds of GT 1 infection (AOR: 3.37; 95% CI: 1.89, 5.99).
Although, HCV GT 1 remains the most prevalent GT, especially among older groups, changes in GT distribution could have significant implications for how HCV might be controlled on a population level and treated on an individual level.
丙型肝炎病毒（HCV）基因型（GT）已成为 HCV 感染诊断和治疗监测的重要指标。在美国（U.S.），报告称慢性感染患者中最常见的感染 GT 是 HCV GT1。然而，在欧洲，最近的研究表明 HCV GT 的流行病学正在发生变化。
我们评估了来自旧金山三个 HCV 感染高危人群的 460 名患者的 HCV GT 分布，并通过出生队列检查模式，以评估时间趋势。多因素逻辑回归用于评估与其他 GT（2、3 和 4）相比，与 GT1 感染相关的独立因素。
总体而言，GT1 占主导地位（72.4%），但年轻的静脉注射吸毒者（IDU）的 GT1 感染比例较低（54.7%），与年长的 IDU 和 HIV 感染者（80.5%和 76.6%）相比。按出生队列分析显示，与出生年份相关的非 GT1 感染比例增加：出生于 1970 年之前与 GT1 的调整后比值比（AOR）独立相关，AOR 为 2.03（95%CI：1.23，3.34）。与白人相比，非裔美国人感染 GT1 的调整后比值比（AOR）也更高（AOR：3.37；95%CI：1.89，5.99）。
尽管 HCV GT1 仍然是最常见的 GT，尤其是在年龄较大的人群中，但 GT 分布的变化可能对 HCV 在人群水平上的控制和个体水平上的治疗产生重大影响。
