University of Oxford, Oxford, UK.
Br J Nutr. 2011 Nov;106(9):1297-309. doi: 10.1017/S0007114511003849. Epub 2011 Aug 3.
The increase in the prevalence of obesity in recent years has prompted research into alternative methods of modulating body weight and body fat. The last decade has reflected this with a surge in studies investigating the potential of green tea as a natural agent of weight loss, with a view to confirming and elucidating the mechanisms underlying its effect on the body. Currently, it is widely believed that the polyphenolic components present in green tea have an anti-obesogenic effect on fat homeostasis, by increasing thermogenesis or reducing fat absorption among other ways. The data published to date, however, are inconsistent, with numerous putative modes of action suggested therein. While several unimodal mechanisms have been postulated, a more plausible explanation of the observed results might involve a multimodal approach. Such a mechanism is suggested here, involving simultaneous inhibition of the enzymes catechol-O-methyltransferase, acetyl-CoA carboxylase, fatty acid synthase and impeding absorption of fat via the gut. An evaluation of the available evidence supports a role of green tea in weight loss; however the extent of the effects obtained is still subject to debate, and requires more objective quantification in future research.
近年来，肥胖症的患病率不断上升，促使人们研究替代方法来调节体重和体脂肪。过去十年的研究反映了这一趋势，大量研究探讨了绿茶作为天然减肥剂的潜力，以期证实并阐明其对人体影响的机制。目前，人们普遍认为，绿茶中存在的多酚成分通过增加产热或减少脂肪吸收等方式对脂肪稳态具有抗肥胖作用。然而，迄今为止发表的数据不一致，其中提出了许多推测的作用模式。虽然已经提出了几种单模态机制，但观察到的结果更可能涉及多模态方法。这里提出了一种这样的机制，涉及同时抑制儿茶酚-O-甲基转移酶、乙酰辅酶 A 羧化酶、脂肪酸合酶的活性，并通过肠道阻止脂肪吸收。对现有证据的评估支持绿茶在减肥中的作用；然而，所获得的效果的程度仍存在争议，需要在未来的研究中进行更客观的量化。
