Department of Oral Physiology, Matsumoto Dental University Graduate School of Dentistry, Shiojiri, Japan.
Eur J Med Res. 2011 Jun 21;16(6):249-52. doi: 10.1186/2047-783x-16-6-249.
Polypropylene (PP), Polyethylene (PE) and polytetrafluoroethylene (FE) are high molecular materials in medical use. They are also used as the negative control materials for ISO 10993-6 international standard biological evaluation of medical devices. We examined tissue reactions to these materials embedded subcutaneously in the dorsal area of male ddY mice. One week and 12 weeks after embedding, the tissue surrounding the embedding site was removed and then histopathological examination was performed. Our results demonstrate that the basic histopathological reaction is the formation of fibrous capsule consisting of granulation tissue around the embedded materials. Based on our results, we believe that the high molecular materials such as, PP, PE and FE, can be considered for medical use as a biomaterials within the body.
聚丙烯（PP）、聚乙烯（PE）和聚四氟乙烯（FE）是医学应用中的高分子材料。它们也被用作医疗器械 ISO 10993-6 国际标准生物学评价的阴性对照材料。我们研究了这些材料在雄性 ddY 小鼠背部皮下植入后的组织反应。在植入后 1 周和 12 周时，切除植入部位周围的组织，然后进行组织病理学检查。我们的结果表明，基本的组织病理学反应是在嵌入材料周围形成由肉芽组织组成的纤维囊。根据我们的结果，我们认为，PP、PE 和 FE 等高分子材料可作为生物材料在体内使用。
