Department of Pediatric Sciences, University of Messina, Messina, Italy.
Horm Res Paediatr. 2011;76(4):221-5. doi: 10.1159/000327587. Epub 2011 Jul 28.
To ascertain the prevalence of Graves' disease (GD) in 1,323 Caucasian children with type 1 diabetes mellitus (T1DM), and to compare the course of GD in T1DM patients with the one observed in 109 Caucasian peer patients with GD but without T1DM (group B).
Only 7 patients (0.53%) of the T1DM series also presented with GD (group A)which was diagnosed many years after diabetes presentation. At GD diagnosis, the prevalence of preclinical hyperthyroidism was higher in group A (p = 0.0001), whereas serum TSH receptor antibodies (TRABs) were higher in group B (p = 0.04). The subsequent course with methimazole therapy and after its withdrawal was very similar in both groups.
GD prevalence in T1DM patients was 0.53%, i.e. almost identical to the one reported in the general population. GD was diagnosed many years after T1DM presentation. At GD diagnosis, the clinical picture was milder and TRAB serum levels were lower in diabetic patients. Preclinical diagnosis and early treatment of GD were not associated with better responsiveness to therapy. Screening programs based on periodical TRAB assessments are not useful in T1DM.
确定 1323 例 1 型糖尿病（T1DM）高加索儿童格雷夫斯病（GD）的患病率，并比较 T1DM 患者 GD 的病程与 109 例高加索 GD 但无 T1DM 同龄患者（B 组）的病程。
T1DM 系列中仅 7 例（0.53%）患者也同时患有 GD（A 组），该组在糖尿病发病多年后确诊。在 GD 诊断时，A 组亚临床甲状腺功能亢进症的患病率更高（p = 0.0001），而 B 组的血清促甲状腺激素受体抗体（TRABs）更高（p = 0.04）。两组在他巴唑治疗后的后续过程及其停药后非常相似。
T1DM 患者 GD 的患病率为 0.53%，与一般人群报告的患病率几乎相同。GD 在 T1DM 发病多年后确诊。在 GD 诊断时，糖尿病患者的临床表现较轻，TRAB 血清水平较低。GD 的临床前期诊断和早期治疗与对治疗的更好反应无关。基于定期 TRAB 评估的筛查计划在 T1DM 中没有用。
