Division of Nephrology, Saint Louis Veterans Affairs Medical Center, Saint Louis, Mo. 63106, USA. zalaly @ gmail.com
Nephron Clin Pract. 2011;119(2):c179-85; discussion c186. doi: 10.1159/000324768. Epub 2011 Jul 28.
Chronic kidney disease (CKD) is associated with increased risk of death. A wave of recent studies used longitudinal data to examine the effect of the rate of decline of kidney function on the risk of death. The results from these studies show that there is an independent and graded association between the rate of kidney function decline and the risk of death. There is a need to incorporate the rate of decline in the definition of CKD. This redefinition of CKD will transform a static definition into a dynamic one that more accurately describes the disease state in an individual patient.
慢性肾脏病（CKD）与死亡风险增加有关。最近的一系列研究使用纵向数据来研究肾功能下降速度对死亡风险的影响。这些研究的结果表明，肾功能下降速度与死亡风险之间存在独立的分级关联。需要在 CKD 的定义中纳入下降速度。这种对 CKD 的重新定义将静态定义转变为动态定义，更准确地描述个体患者的疾病状态。
