信号通过再循环分选。
Signalling gets sorted by retromer.
机构信息
Growth and Development, Biozentrum, University of Basel, Basel, Switzerland.
出版信息
EMBO J. 2011 Aug 3;30(15):2988-9. doi: 10.1038/emboj.2011.232.
EMBO J 29 24, 4094–4105 (2010); published online November 12 2010 Nat Cell Biol (2011); advance online publication 3 July 2011; doi:; DOI: 10.1038/ncb2281 Wnt proteins are secreted glycoproteins required for intercellular communication and important for development and tissue homoeostasis. Wnts are secreted through association to the sorting receptor Wntless, which promotes transport of Wnt from the trans-Golgi network (TGN) to the plasma membrane. Harterink et al (2011) and Silhankova et al (2010) have investigated the intracellular recycling of the Wnt-sorting receptor and identified a novel retromer-dependent traffic route from early endosomes to the TGN that is dependent on the sorting nexin SNX3 and is regulated by PI3P levels on early endosomes.
EMBO J 29 24, 4094–4105 (2010); published online November 12 2010 Nat Cell Biol (2011); advance online publication 3 July 2011; doi:; DOI: 10.1038/ncb2281 Wnt 蛋白是一种分泌型糖蛋白，对于细胞间通讯至关重要，对发育和组织内稳态也很重要。Wnt 蛋白通过与分选受体 Wntless 结合而被分泌，Wntless 促进 Wnt 从高尔基体运输到质膜。Harterink 等人（2011 年）和 Silhankova 等人（2010 年）研究了 Wnt 分选受体的细胞内循环，发现了一种从早期内体到高尔基体的新型反式高尔基体网络（retromer）依赖的运输途径，该途径依赖于分选连接蛋白 SNX3，并且受早期内体上 PI3P 水平的调节。
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