没有证据表明长片段纯合子与阿尔茨海默病有关。
No evidence that extended tracts of homozygosity are associated with Alzheimer's disease.
机构信息
MRC Centre for Neuropyschiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University, Heath Park.
出版信息
Am J Med Genet B Neuropsychiatr Genet. 2011 Dec;156B(7):764-71. doi: 10.1002/ajmg.b.31216. Epub 2011 Aug 2.
We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.
我们试图在一个包含 1955 例阿尔茨海默病病例和 955 例经过 529205 个常染色体单核苷酸多态性基因分型的老年筛查对照的全基因组关联数据集的范围内，调查扩展的纯合性区域的贡献。纯合性区域可能标志着从共同祖先遗传的区域，如果在病例中比对照中更频繁地观察到，就可以反映疾病的位置。我们没有发现与对照组相比，阿尔茨海默病病例中有过多的纯合性区域，也没有发现单个纯合性区域与阿尔茨海默病有关。
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