Sanders D B, Howard J F, Johns T R
Neurology. 1979 Jan;29(1):68-76. doi: 10.1212/wnl.29.1.68.
One-hundred-sixty single-fiber EMG studies of the extensor digitorum communis muscle were performed on 127 patients with myasthenia gravis; 131 demonstrated defective neuromuscular transmission. Jitter determinations in the biceps, deltoid or frontalis muscles increased the diagnostic yield significantly. Evoked-potential EMG studies were abnormal in less than 50 percent of patients in whom they were performed. The most sensitive criterion of abnormality was the percentage of fibers with increased jitter; the sensitivity of the test was enhanced, however, if the mean jitter of the tested muscle was also used as a criterion of abnormality. Since increased jitter may also be seen in primary muscle and nerve disease, these disorders must be excluded by other means before diagnosing myasthenia gravis on the basis of the single-fiber studies.
对127例重症肌无力患者的160次指总伸肌单纤维肌电图研究进行了分析；其中131例显示神经肌肉传递存在缺陷。对肱二头肌、三角肌或额肌进行的颤抖测定显著提高了诊断阳性率。在进行诱发电位肌电图检查的患者中，不到50%的患者检查结果异常。最敏感的异常标准是颤抖增加的纤维百分比；然而，如果将被测肌肉的平均颤抖也用作异常标准，则该测试的敏感性会提高。由于在原发性肌肉和神经疾病中也可能出现颤抖增加的情况，因此在根据单纤维研究诊断重症肌无力之前，必须通过其他方法排除这些疾病。
