Connolly S, Smith D G, Doyle D, Fowler C J
Department of Clinical Neurophysiology, Middlesex Hospital, London, UK.
J Neurol. 1993 Jul;240(7):435-8. doi: 10.1007/BF00867358.
Single fibre electromyography of extensor digitorum communis muscle (EDC) was performed on 35 patients with chronic fatigue, the majority of whom also had creatine kinase estimation and biopsy of EDC. The subjects were categorised as having an acute-onset post-viral fatigue syndrome, a non-specific chronic fatigue or possible muscle disease in view of pronounced myalgia. Of 11 subjects who had myalgia as a significant symptom, abnormalities in fibre density were found in 6, and 5 of these had some non-specific abnormalities on muscle biopsy, with creatine kinase levels being normal in all cases. Fibre density estimation may be a useful way of identifying a subgroup of chronic fatigue sufferers with a possible primary muscle disorder.
对35例慢性疲劳患者进行了指总伸肌（EDC）单纤维肌电图检查，其中大多数患者还进行了肌酸激酶测定和EDC活检。鉴于明显的肌痛，这些受试者被分类为患有急性起病的病毒感染后疲劳综合征、非特异性慢性疲劳或可能的肌肉疾病。在11例以肌痛为显著症状的受试者中，6例发现纤维密度异常，其中5例肌肉活检有一些非特异性异常，所有病例的肌酸激酶水平均正常。纤维密度测定可能是识别患有可能原发性肌肉疾病的慢性疲劳患者亚组的一种有用方法。
