Fowles Robert G, Mootoo Baldwin S, Ramsewak Russel S, Reynolds William F, Nair Muraleedharan G G
Department of Agricultural, Food and Nutritional Science, T6G 2P5, University of Alberta, Edmonton, Alberta, Canada.
Nat Prod Commun. 2011 Jun;6(6):785-7.
In this study the antioxidant activity of natural limonoids from Meliaceae swietenolide (1), 3,6-O,O-diacetylswietenolide (2), swietenine (3), swietemahonin G (4) and 2-hydroxyswietenine (5) were investigated along with the semi-synthetic analogues (6-25) of compounds 1, 3-4. Lipid peroxidation (LPO) inhibitory assays revealed 85.6, 13.3, 77.3, 61.2 and 24.6% inhibition for the natural compounds 1-5. Excellent antioxidant activity was seen for the semi-synthetic analogues 10 (98.3%), 16-17, 21-22 and 25 (100%), which were more active than the positive controls BHA (91.3%) and TBHQ (95.7%).
在本研究中，对楝科植物中的天然柠檬苦素类化合物（1）、3,6 - O,O - 二乙酰基苦楝醇（2）、苦楝碱（3）、苦楝马诺宁G（4）和2 - 羟基苦楝碱（5）以及化合物1、3 - 4的半合成类似物（6 - 25）的抗氧化活性进行了研究。脂质过氧化（LPO）抑制试验表明，天然化合物1 - 5的抑制率分别为85.6%、13.3%、77.3%、61.2%和24.6%。半合成类似物10（98.3%）、16 - 17、21 - 22和25（100%）表现出优异的抗氧化活性，其活性高于阳性对照丁基羟基茴香醚（BHA，91.3%）和叔丁基对苯二酚（TBHQ，95.7%）。
