叶下珠中的柠檬苦素。

Limonoids from the leaves of Cipadessa baccifera.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.

出版信息

J Nat Prod. 2010 Aug 27;73(8):1327-31. doi: 10.1021/np900852d.

DOI:10.1021/np900852d

PMID:20666364

Abstract

Eight new limonoids with four different structural frameworks, including gedunin (1, 2), havanensin (3, 4), mexicanolide (5, 6), and methyl angolensate types (7, 8), together with six known limonoids, were isolated from the leaves of Cipadessa baccifera. Compounds 2 and 5 exhibited moderate cytotoxicity against the HL-60 cell line with an IC(50) value of 20 microM.

摘要

从八角枫科八角枫属植物瓜木的叶中分离得到 8 个新的具有 4 种不同结构骨架的倍半萜类化合物，包括格冬宁（1，2）、哈瓦那宁（3，4）、墨西哥醇内酯（5，6）和甲基当归叶酯型（7，8），以及 6 个已知的倍半萜类化合物。化合物 2 和 5 对 HL-60 细胞系表现出中等的细胞毒性，IC（50）值为 20 microM。