钩果藤属叶中的黄烷和墨西哥诺内酯型柠檬苦素。

Phragmalin- and mexicanolide-type limonoids from the leaves of Trichilia connaroides.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.

出版信息

J Nat Prod. 2011 Feb 25;74(2):152-7. doi: 10.1021/np100428u. Epub 2011 Jan 26.

DOI:10.1021/np100428u

PMID:21268637

Abstract

Phytochemical investigation of the leaves of Trichilia connaroides afforded 12 new limonoids with phragmalin- (1-11) and mexicanolide-type skeletons (12). The structures of these limonoids, including the absolute configuration of 3, were determined by spectroscopic analysis. Compounds 6 and 8 showed moderate cytotoxicity against HL-60 cells.

摘要

对 Trichilia connaroides 的叶子进行的植物化学研究得到了 12 种具有 phragmalin- (1-11) 和 mexicanolide 型骨架的新柠檬苦素（12）。通过光谱分析确定了这些柠檬苦素的结构，包括 3 的绝对构型。化合物 6 和 8 对 HL-60 细胞表现出中等的细胞毒性。