Peters L J
Division of Radiotherapy, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Radiother Oncol. 1990 Mar;17(3):177-90. doi: 10.1016/0167-8140(90)90202-8.
This lecture reviews the history and current status of attempts to correlate the outcome of radiation therapy with estimates of tumor cell radiosensitivity, made by either histologic assessment of tumors irradiated in vivo or by assays for the survival of tumor cells irradiated in vitro. Genetically determined variability in the radiosensitivity of normal tissue cells from different individuals is also discussed in terms of its effect on the determination of "tolerance" doses and the possible correlation between tumor cell and normal tissue cell radiosensitivity in a given patient. It is concluded that measurement of both tumor cell and normal tissue cell radiosensitivities, along with other radiobiologically-based assays, will improve our ability to predict treatment outcome and provide the basis for further therapeutic advances in radiation oncology.
本讲座回顾了将放射治疗结果与肿瘤细胞放射敏感性估计值相关联的尝试的历史和现状，这些估计值是通过对体内照射肿瘤的组织学评估或体外照射肿瘤细胞的存活测定得出的。还讨论了不同个体正常组织细胞放射敏感性的遗传决定变异性对“耐受”剂量测定的影响，以及给定患者中肿瘤细胞和正常组织细胞放射敏感性之间的可能相关性。结论是，测量肿瘤细胞和正常组织细胞的放射敏感性，以及其他基于放射生物学的测定，将提高我们预测治疗结果的能力，并为放射肿瘤学的进一步治疗进展提供基础。
