Diabetes and Nutritional Sciences Division, King's College London-KCL, London, UK.
Aliment Pharmacol Ther. 2011 Oct;34(7):687-701. doi: 10.1111/j.1365-2036.2011.04792.x. Epub 2011 Aug 4.
Orofacial granulomatosis is a rare chronic granulomatous inflammatory disease of the lips, face and mouth. The aetiology remains unclear but may involve an allergic component. Improvements have been reported with cinnamon- and benzoate-free diets.
To explore the prevalence of compound and food sensitivity and examine the dietary treatments used in orofacial granulomatosis.
A comprehensive literature search was carried out and relevant studies from January 1933 to January 2010 were identified using the electronic database search engines; AGRIS 1991-2008, AMED 1985-2008, British Nursing and Index archive 1985-2008, EMBASE 1980-2008, evidence based medicine review databases (e.g. Cochrane DSR), International Pharmaceutical and Medline 1950-2008.
Common sensitivities identified, predominantly through patch testing, were to benzoic acid (36%) food additives (33%), perfumes and flavourings (28%), cinnamaldehyde (27%), cinnamon (17%), benzoates (17%) and chocolate (11%). The cinnamon- and benzoate-free diet has been shown to provide benefit in 54-78% of patients with 23% requiring no adjunctive therapies. A negative or positive patch test result to cinnamaldehyde, and benzoates did not predict dietary outcome. The most concentrated source of benzoate exposure is from food preservatives. Use of liquid enteral formulas can offer a further dietary therapy, particularly in children with orofacial granulomatosis.
Management of orofacial granulomatosis is challenging but cinnamon- and benzoate-free diets appear to have a definite role to play.
口面肉芽肿病是一种罕见的唇部、面部和口腔慢性肉芽肿性炎症性疾病。病因尚不清楚，但可能涉及过敏成分。肉桂和安息香酸盐饮食可改善病情。
探讨口面肉芽肿病的复合和食物敏感性的流行情况，并研究其饮食治疗方法。
对 1933 年 1 月至 2010 年 1 月期间的电子数据库搜索引擎，包括 AGRIS 1991-2008、AMED 1985-2008、英国护理与索引档案 1985-2008、EMBASE 1980-2008、循证医学评价数据库（如 Cochrane DSR）、国际药学和医学文献 1950-2008 进行了全面的文献检索，并确定了相关研究。
通过斑贴试验发现的常见敏感性主要包括苯甲酸（36%）、食品添加剂（33%）、香水和香料（28%）、肉桂醛（27%）、肉桂（17%）、苯甲酸盐（17%）和巧克力（11%）。肉桂和安息香酸盐饮食已被证明在 54%-78%的患者中有效，23%的患者无需辅助治疗。肉桂醛和苯甲酸盐斑贴试验结果为阴性或阳性并不能预测饮食结果。苯甲酸暴露的最集中来源是食品防腐剂。液体肠内配方的使用可以提供进一步的饮食治疗，特别是对口面肉芽肿病患儿。
口面肉芽肿病的治疗具有挑战性，但肉桂和安息香酸盐饮食似乎具有明确的作用。
