Armstrong D K, Biagioni P, Lamey P J, Burrows D
Department of Dermatology, Royal Group of Hospitals, Belfast, Northern Ireland.
Am J Contact Dermat. 1997 Mar;8(1):35-8.
Orofacial granulomatosis is a clinical entity presenting with chronic swelling of the oral or facial tissues in association with histological evidence of noncaseating granulomatous inflammation. Its cause remains unclear, but a possible role of contact sensitivity to dietary components has been proposed.
This study was performed to document the prevalence of contact sensitivity to food additives in patients with orofacial granulomatosis and assess the role of elimination diets in management.
Successive patients with a clinical diagnosis of orofacial granulomatosis were patch tested to the European Standard series and an Oral Battery containing common food additives. In addition, testing for immediate contact reactions to components of the Oral Battery was performed. In selected cases, appropriate elimination diets were implemented.
Forty-eight patients were investigated. Ten showed positive reactions to components of the Oral Battery on standard patch testing and, of these, seven showed improvement on an elimination diet.
Orofacial granulomatosis is a heterogenous clinical entity. Patch testing permits identification of a subgroup of patients likely to benefit from dietary manipulation and allows more appropriate targeting of such treatment.
口面部肉芽肿病是一种临床病症，表现为口腔或面部组织的慢性肿胀，并伴有非干酪样肉芽肿性炎症的组织学证据。其病因尚不清楚，但已提出饮食成分接触性敏感可能起作用。
本研究旨在记录口面部肉芽肿病患者对食品添加剂接触性敏感的患病率，并评估排除饮食在治疗中的作用。
对临床诊断为口面部肉芽肿病的连续患者进行欧洲标准系列和包含常见食品添加剂的口腔组的斑贴试验。此外，还对口腔组成分进行即刻接触反应测试。在选定病例中，实施适当的排除饮食。
对48例患者进行了调查。10例在标准斑贴试验中对口腔组成分呈阳性反应，其中7例在排除饮食后病情改善。
口面部肉芽肿病是一种异质性临床病症。斑贴试验可识别可能从饮食调整中获益的患者亚组，并使此类治疗的靶向性更强。
