Masclee A A, de Best A C, de Graaf R, Cluysenaer O J, Jansen J B
Dept. of Internal Medicine, University Hospital Nijmegen, The Netherlands.
Scand J Gastroenterol. 1990 Mar;25(3):225-30.
The results of ambulatory 24-h esophageal pH monitoring in 67 patients with gastroesophageal reflux symptoms (endoscopic esophagitis, n = 44; normal endoscopy, n = 23) were compared with those of 27 normal subjects without reflux symptoms. Patients with reflux symptoms had significantly increased gastroesophageal reflux compared with normal subjects. Acid reflux time was significantly (p less than 0.001) correlated with the severity of endoscopic esophagitis. Linear discriminant analysis was used to differentiate, for each reflux variable, between patients and controls. When the percentage of overall time at pH below 4 was used as a single determinant of gastroesophageal reflux, the sensitivity and specificity were 81% and 85%, respectively, with 4% as upper limit of normal. Pathologic reflux was found in 61% of the patients with negative endoscopy. Long-term ambulatory pH-metry is of clinical value in detecting pathologic reflux in symptomatic patients with negative endoscopy.
对67例有胃食管反流症状的患者（内镜检查发现食管炎44例，内镜检查正常23例）进行24小时动态食管pH监测，将结果与27例无反流症状的正常受试者进行比较。有反流症状的患者与正常受试者相比，胃食管反流明显增加。酸反流时间与内镜食管炎的严重程度显著相关（p<0.001）。采用线性判别分析对每个反流变量在患者和对照组之间进行区分。当pH值低于4的总时间百分比作为胃食管反流的单一决定因素时，敏感性和特异性分别为81%和85%，正常上限为4%。内镜检查阴性的患者中61%存在病理性反流。长期动态pH测量对检测内镜检查阴性的有症状患者的病理性反流具有临床价值。
