Department of Neurology, Northwestern University, Chicago, IL 60611, USA.
Epilepsy Behav. 2011 Oct;22(2):401-3. doi: 10.1016/j.yebeh.2011.06.036. Epub 2011 Aug 4.
Epidemiological evidence associating ictal hypoventilation during focal seizures with a heightened risk for subsequent sudden unexpected death in epilepsy (SUDEP) is lacking. We describe a patient with temporal lobe epilepsy with two focal seizures recorded in the epilepsy monitoring unit that were associated with central apnea lasting 57 and 58 seconds. During these events, she demonstrated oxygen desaturation down to 68 and 62%. The patient subsequently died at home from autopsy-confirmed SUDEP. The family was not alerted of any seizure activity by the auditory alarm system in her room nor by sleeping in the adjacent room with open doors. This case emphasizes the fact that ictal hypoxia and SUDEP may occur in seizures without noticeable convulsive activity. The report gives credibility to the growing body of literature suggesting that epilepsies affecting the autonomic nervous system may predispose to SUDEP independent of the effects of a secondary generalized convulsion.
目前缺乏局灶性癫痫发作时发作性低通气与癫痫后猝然意外死亡（SUDEP）风险增加相关的流行病学证据。我们描述了一名颞叶癫痫患者，在癫痫监测单元记录到两次局灶性癫痫发作，与持续 57 和 58 秒的中枢性呼吸暂停相关。在这些事件中，她的氧饱和度下降到 68%和 62%。患者随后在家中死于经尸检证实的 SUDEP。家属没有被她房间里的听觉报警系统或打开门睡在相邻房间里的声音惊醒。该病例强调了这样一个事实，即无明显惊厥活动的癫痫发作可能伴有发作性缺氧和 SUDEP。该报告为越来越多的文献提供了可信度，这些文献表明，影响自主神经系统的癫痫可能会导致 SUDEP，而与继发性全身性惊厥的影响无关。
