Department of Cardiology, Peking University Third Hospital, China.
J Occup Health. 2011;53(5):334-42. doi: 10.1539/joh.11-0023-oa. Epub 2011 Aug 5.
Previous studies examining the association between job stress and blood lipids have produced mixed findings. We sought to investigate the association between job stress and blood lipids among Chinese workers.
A total of 544 subjects (367 men and 177 women) without known diseases from the Stress and Health in Shenzhen Workers (SHISO) cross-sectional study were analyzed. Job stress was evaluated by the effort-reward imbalance (ERI) model. The associations between job stress and blood lipids, such as for total cholesterol (TCHO), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), were explored by multiple linear regression. The association between job stress and combined dyslipidemia was examined by multiple logistic regression.
Compared with their corresponding low level groups, groups with high levels of effort, overcommitment and ERI had a significantly increased risk of combined dyslipidemia with adjusted odd ratios (ORs) of 3.5 (95% CI 1.8-6.7), 4.2 (95% CI 2.3-7.7) and 2.7 (95% CI 1.5-5.1), respectively, whereas high rewards significantly reduced the risk of combined dyslipidemia (adjusted OR 0.3, 95% CI 0.2-0.6) compared with low rewards. Effort, overcommitment and ERI were significantly positively related to TG and LDL-C, while rewards were inversely related to them. No significant associations were observed between job stress and TCHO and HDL-C. The results were similar for men and women.
Effort, overcommitment, low reward and ERI increased the risk of dyslipidemia among Chinese workers, and they were significantly associated with TG and LDL-C rather than TCHO or HDL-C. Increasing blood lipids may be the possible link between job stress and coronary heart disease.
以往研究工作压力与血脂之间的关系得出的结果并不一致。本研究旨在探究中国工人工作压力与血脂之间的关系。
本研究纳入了来自深圳压力与健康研究（SHISO）的横断面研究中的 544 名（男 367 名，女 177 名）无已知疾病的研究对象。采用努力-回报失衡模型（ERI）评估工作压力。采用多元线性回归分析探讨工作压力与总胆固醇（TCHO）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）等血脂指标之间的关系。采用多因素 logistic 回归分析工作压力与血脂异常的关系。
与低水平组相比，高水平的努力、过度投入和 ERI 与血脂异常的风险增加显著相关，调整后的比值比（OR）分别为 3.5（95%CI 1.8-6.7）、4.2（95%CI 2.3-7.7）和 2.7（95%CI 1.5-5.1），而高回报与低回报相比，显著降低了血脂异常的风险（调整 OR 0.3，95%CI 0.2-0.6）。努力、过度投入和 ERI 与 TG 和 LDL-C 呈显著正相关，而回报与它们呈显著负相关。工作压力与 TCHO 和 HDL-C 之间无显著相关性。男性和女性的结果相似。
在中国工人中，努力、过度投入、低回报和 ERI 增加了血脂异常的风险，并且它们与 TG 和 LDL-C 显著相关，而与 TCHO 或 HDL-C 无显著相关性。增加的血脂可能是工作压力与冠心病之间的可能联系。
