Xu Weixian, Chen Baoxia, Guo Lijun, Li Zhaoping, Zhao Yiming, Zeng Hui
Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
Am J Ind Med. 2015 Jul;58(7):773-9. doi: 10.1002/ajim.22470.
Chronic inflammation may play an important role in linking job stress to atherosclerosis. We sought to investigate the relationship between job stress and high-sensitivity C-reactive protein (hs-CRP) among Chinese workers.
A total of 731 subjects (506 men and 225 women) were analyzed. Job stress was evaluated by effort-reward imbalance (ERI) model.
Among men, after adjustment for confounders, effort, overcommitment, and ERI were significantly positively correlated with hs-CRP; and reward was significantly inversely related with hs-CRP; high level of effort, overcommitment, or ERI, respectively, significantly increased the odds of high hs-CRP with ORs of 2.0, 3.5, and 3.3 (all P<0.001), compared with the corresponding low level groups. Among women, high overcommitment or ERI also increased risk of high hs-CRP with ORs of 2.8, and 4.1 (P<0.05).
High effort, overcommmitment, and ERI were positively associated with hs-CRP. Inflammation indicated by hs-CRP may be one of important mediators linking job stress and atherosclerosis.
慢性炎症可能在工作压力与动脉粥样硬化的关联中起重要作用。我们试图在中国工人中研究工作压力与高敏C反应蛋白（hs-CRP）之间的关系。
共分析了731名受试者（506名男性和225名女性）。工作压力通过付出-回报失衡（ERI）模型进行评估。
在男性中，调整混杂因素后，付出、过度投入和ERI与hs-CRP显著正相关；回报与hs-CRP显著负相关；与相应的低水平组相比，高水平的付出、过度投入或ERI分别使hs-CRP升高的几率显著增加，比值比（OR）分别为2.0、3.5和3.3（均P<0.001）。在女性中，高过度投入或ERI也增加了hs-CRP升高的风险，OR分别为2.8和4.1（P<0.05）。
高付出、过度投入和ERI与hs-CRP呈正相关。hs-CRP所表明的炎症可能是连接工作压力和动脉粥样硬化的重要中介因素之一。
